Ruta Nacional 40 Mendoza to Neuquén Wine Country Traverse

This 400-kilometer stretch of Argentina’s iconic Ruta 40 runs from Mendoza’s world-class wine country into northern Patagonia, crossing the Colorado River boundary that marks the transition from desert to steppe. The route passes through Malargüe with its volcanic landscape and mysterious Payunia lava fields, then climbs through mountain passes with clear views of Aconcagua on good days. River crossings become technical after heavy rains, particularly at Arroyo Grande where the ford can turn nasty without warning.

Mostly gravel and dirt with some paved sections – any 4WD handles it fine, though high clearance helps with washouts. March through November offers the best weather window, avoiding summer flash floods and winter snow in the passes. Stock up on fuel in Malargüe as stations get sparse heading south. This is Argentina at its most authentic – gauchos, wine country, endless skies, and the kind of empty horizons that remind you why people cross continents for this drive.